Cetrotide

DRUG DESCRIPTION

Cetrotide® (cetrorelix acetate for injection) is a synthetic decapeptide
with gonadotropin- releasing hormone (GnRH) antagonistic activity. Cetrorelix
acetate is an analog of native GnRH with substitutions of amino acids at positions
1, 2, 3, 6, and 10. The molecular formula is Acetyl-D-3-(2´-naphtyl)-alanine-D-4-chlorophenylalanine-D-3-(3´-pyridyl)-
alanine-L-serine-L-tyrosine-D-citruline-L-leucine-L-arginine-L-proline-D-alanine-amide,
and the molecular weight is 1431.06, calculated as the anhydrous free base.
The structural formula is as follows:

(Ac-0-Nal 1 -D-Cpa2-D-Pal3-Ser4-Tyr5-D < it6-Leu7-Arg8-Pro9-D-Ala
10-NH2)

Cetrotide® (cetrorelix acetate for injection) 0.25 mg or 3 mg is a sterile lyophilized powder intended for subcutaneous injection after reconstitution with Sterile Water for Injection, USP (pH 5-8), that comes supplied in either a 1.0 mL (for 0.25 mg vial) or 3.0 mL (for 3 mg vial) pre-filled syringe. Each vial of Cetrotide® (cetrorelix) 0.25 mg (multiple dose regimen) contains 0.26-0.27 mg cetrorelix acetate, equivalent to 0.25 mg cetrorelix, and 54.80 mg mannitol. Each vial of Cetrotide (cetrorelix) ® 3 mg (single dose regimen) contains 3.12-3.24 mg cetrorelix acetate, equivalent to 3 mg cetrorelix, and 164.40 mg mannitol.

What are the possible side effects of cetrorelix (Cetrotide)?

Stop using cetrorelix and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Approximately 3.5 % of female patients treated with cetrorelix have developed ovarian hyperstimulation syndrome (OHSS). Symptoms of OHSS include severe pelvic pain, swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, low urine output, diarrhea, and nausea or vomiting. OHSS can be fatal. Notify your doctor...

Read All Potential Side Effects and See Pictures of Cetrotide »

What are the precautions when taking cetrorelix (Cetrotide)?

Before using cetrorelix, tell your doctor or pharmacist if you are allergic to it; or to other hormones (e.g., GnRH); or if you have any other allergies. This product may contain inactive ingredients (such as mannitol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of severe allergic reactions, kidney disease.

This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately.

It is not known whether this drug passes into breast milk. Breast-feeding while using this drug is not recommended because it may harm the nursing infant. Consult your doctor...

Read All Potential Precautions of Cetrotide »

Cetrotide Consumer (continued)

SIDE EFFECTS: Nausea, headache, and pain/bruising/redness/swelling/itching at the injection site may occur. If any of these effects persist or worsen, tell your doctor promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these rare but very serious side effects occur: severe pain/swelling/cramping in the abdomen.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using cetrorelix, tell your doctor or pharmacist if you are allergic to it; or to other hormones (e.g., GnRH); or if you have any other allergies. This product may contain inactive ingredients (such as mannitol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of severe allergic reactions, kidney disease.

This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately.

It is not known whether this drug passes into breast milk. Breast-feeding while using this drug is not recommended because it may harm the nursing infant. Consult your doctor before breast-feeding.

Cetrotide Patient Information Including Side Effects

Brand Names: Cetrotide

Generic Name: cetrorelix (injectable) (Pronunciation: SE troe REL ix)

• What is cetrorelix (Cetrotide)?


• What are the possible side effects of cetrorelix (Cetrotide)?


• What is the most important information I should know about cetrorelix (Cetrotide)?


• What should I discuss with my healthcare provider before using cetrorelix (Cetrotide)?


• How should I use cetrorelix (Cetrotide)?


• What happens if I miss a dose (Cetrotide)?


• What happens if I overdose (Cetrotide)?


• What should I avoid while using cetrorelix (Cetrotide)?


• What other drugs will affect cetrorelix (Cetrotide)?


• Where can I get more information?

What is cetrorelix (Cetrotide)?

Cetrorelix blocks the effects of the naturally occurring gonadotropin-releasing hormone (GnRH). GnRH controls the release of another hormone, luteinizing hormone (LH), which induces ovulation (release of an egg from the ovary) during the menstrual cycle. During hormone treatment for ovarian stimulation, premature ovulation may lead to eggs that are not suitable for fertilization. Cetrorelix blocks this undesirable premature ovulation.

Cetrorelix is used to prevent premature ovulation during controlled ovarian stimulation.

Cetrorelix may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of cetrorelix (Cetrotide)?

Stop using cetrorelix and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Approximately 3.5 % of female patients treated with cetrorelix have developed ovarian hyperstimulation syndrome (OHSS). Symptoms of OHSS include severe pelvic pain, swelling of the hands or legs, abdominal pain and swelling, shortness of breath, weight gain, low urine output, diarrhea, and nausea or vomiting. OHSS can be fatal. Notify your doctor immediately or seek emergency medical attention if you develop any of these symptoms.

Other side effects may also occur. Notify your doctor if you experience

• nausea;


• headache; or


• redness, bruising, itching, or swelling at the injection site.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cetrorelix (Cetrotide)?

Do not use cetrorelix if you are pregnant. Cetrorelix is in the FDA pregnancy category X. This means that cetrorelix is known to cause birth defects.

Talk to your doctor before using cetrorelix if you have kidney disease or any renal (kidney) problems. Cetrorelix should not be used in patients with severe renal impairment.

Related Drug Centers

• Cetrotide

Fortaz

DRUG DESCRIPTION

Ceftazidime is a semisynthetic, broad-spectrum, beta-lactam antibiotic for
parenteral administration. It is the pentahydrate of pyridinium, 1-[[7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,
hydroxide, inner salt, [6R-[6α,7β(Z)]]. It has the following structure:

The empirical formula is C₂₂H₃₂N₆O₁₂S₂,
representing a molecular weight of 636.6.

FORTAZ is a sterile, dry-powdered mixture of ceftazidime pentahydrate and sodium carbonate. The sodium carbonate at a concentration of 118 mg/g of ceftazidime activity has been admixed to facilitate dissolution. The total sodium content of the mixture is approximately 54 mg (2.3 mEq)/g of ceftazidime activity.

FORTAZ (ceftazidime) in sterile crystalline form is supplied in vials equivalent to 500 mg, 1 g, 2 g, or 6 g of anhydrous ceftazidime and in ADD-Vantage® vials equivalent to 1 or 2 g of anhydrous ceftazidime. Solutions of FORTAZ (ceftazidime) range in color from light yellow to amber, depending on the diluent and volume used. The pH of freshly constituted solutions usually ranges from 5 to 8.

FORTAZ (ceftazidime) is available as a frozen, iso-osmotic, sterile, nonpyrogenic solution with 1 or 2 g of ceftazidime as ceftazidime sodium premixed with approximately 2.2 or 1.6 g, respectively, of Dextrose Hydrous, USP. Dextrose has been added to adjust the osmolality. Sodium hydroxide is used to adjust pH and neutralize ceftazidime pentahydrate free acid to the sodium salt. The pH may have been adjusted with hydrochloric acid. Solutions of premixed FORTAZ (ceftazidime) range in color from light yellow to amber. The solution is intended for intravenous (IV) use after thawing to room temperature. The osmolality of the solution is approximately 300 mOsmol/kg, and the pH of thawed solutions ranges from 5 to 7.5.

The plastic container for the frozen solution is fabricated from a specially designed multilayer plastic, PL 2040. Solutions are in contact with the polyethylene layer of this container and can leach out certain chemical components of the plastic in very small amounts within the expiration period. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

What are the possible side effects of ceftazidime injection (Fortaz, Tazicef)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;


• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;


• swelling, pain, or irritation where the injection was given;


• cold feeling, discoloration, or skin changes in your...

Read All Potential Side Effects and See Pictures of Fortaz »

Fortaz Patient Information Including Side Effects

Brand Names: Fortaz, Tazicef

Generic Name: ceftazidime injection (Pronunciation: sef TAY zi deem)

• What is ceftazidime injection (Fortaz)?


• What are the possible side effects of ceftazidime injection (Fortaz)?


• What is the most important information I should know about ceftazidime injection (Fortaz)?


• What should I discuss with my health care provider before using ceftazidime injection (Fortaz)?


• How should I use ceftazidime injection (Fortaz)?


• What happens if I miss a dose (Fortaz)?


• What happens if I overdose (Fortaz)?


• What should I avoid while using ceftazidime injection (Fortaz)?


• What other drugs will affect ceftazidime injection (Fortaz)?


• Where can I get more information?

What is ceftazidime injection (Fortaz)?

Ceftazidime is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It works by fighting bacteria in your body.

Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms.

Ceftazidime may also be used for other purposes not listed in this medication guide.

What are the possible side effects of ceftazidime injection (Fortaz)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;


• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;


• swelling, pain, or irritation where the injection was given;


• cold feeling, discoloration, or skin changes in your fingers;


• seizure (black-out or convulsions);


• white patches or sores inside your mouth or on your lip; or


• jaundice (yellowing of the eyes or skin).

Less serious side effects may include:

• nausea, vomiting, diarrhea, stomach pain;


• headache, dizziness;


• numbness or tingly feeling; or


• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about ceftazidime injection (Fortaz)?

Do not use this medication if you are allergic to ceftazidime, or to similar antibiotics, such as Ceclor, Ceftin, Cefzil, Duricef, Keflex, Omnicef, Spectracef, Suprax, and others.

Before using this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have liver or kidney disease, diabetes, heart failure, cancer, a stomach or intestinal disorder, or if you are malnourished.

Ceftazidime can make birth control pills less effective, which may result in pregnancy. Tell your doctor if you are taking birth control pills to prevent pregnancy. You may need to use another form of birth control during treatment with ceftazidime.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ceftazidime will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

This medication can cause you to have unusual results with certain lab tests to check for glucose (sugar) in the urine. Tell any doctor who treats you that you are using ceftazidime.

Related Drug Centers

• Fortaz

Winstrol

(Generic versions may still be available.)

DRUG DESCRIPTION

WINSTROL (anabolic steroids) , brand of stanozolol tablets, is an anabolic steroid, a synthetic derivative of testosterone. Each tablet for oral administration contains 2 mg of stanozolol. It is designated chemically as 17-methyl-2' H  -5(alpha)-androst-2-eno[3,2- c  ]pyrazol-17(beta)-ol.

Inactive Ingredients:   Dibasic Calcium Phosphate, D&C Red #28, FD&C Red #40, Lactose, Magnesium Stearate, Starch.

What are the possible side effects of stanozolol (Winstrol)?

In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.

If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of the throat;...

Read All Potential Side Effects and See Pictures of Winstrol »

Winstrol Patient Information Including Side Effects

Brand Names: Winstrol

Generic Name: stanozolol (Pronunciation: stah NO zo lall)

• What is stanozolol (Winstrol)?


• What are the possible side effects of stanozolol (Winstrol)?


• What is the most important information I should know about stanozolol (Winstrol)?


• What should I discuss with my healthcare provider before taking stanozolol (Winstrol)?


• How should I take stanozolol (Winstrol)?


• What happens if I miss a dose (Winstrol)?


• What happens if I overdose (Winstrol)?


• What should I avoid while taking stanozolol (Winstrol)?


• What other drugs will affect stanozolol (Winstrol)?


• Where can I get more information?

What is stanozolol (Winstrol)?

Stanozolol is a man-made steroid, similar to the a naturally occurring steroid testosterone.

Stanozolol is used in the treatment of hereditary angioedema, which causes episodes of swelling of the face, extremities, genitals, bowel wall, and throat. Stanozolol may decrease the frequency and severity of these attacks.

Stanozolol may also be used for purposes other than those listed here.

What are the possible side effects of stanozolol (Winstrol)?

In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.

If you experience any of the following serious side effects, contact your doctor immediately or seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);


• swelling of the arms or legs (especially ankles);


• frequent or persistent erections, or breast tenderness or enlargement (male patients); or


• voice changes (hoarseness, deepening), hair loss, facial hair growth, clitoral enlargement, or menstrual irregularities (female patients).

Other less serious side effects may also occur. Talk to your doctor if you experience

• new or worsening acne;


• difficulty sleeping;


• headache; or


• changes in sexual desire.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about stanozolol (Winstrol)?

In rare cases, serious and even fatal cases of liver problems have developed during treatment with stanozolol. Contact your doctor immediately if you experience abdominal pain, light colored stools, dark colored urine, unusual fatigue, nausea or vomiting, or yellowing of the skin or eyes. These may be early signs of liver problems.

Related Drug Centers

• Winstrol

BioThrax

DRUG DESCRIPTION

BioThrax, Anthrax Vaccine Adsorbed, is a sterile, milky-white suspension for
intramuscular injections made from cell-free filtrates of microaerophilic cultures
of an avirulent, nonencapsulated strain of Bacillus anthracis. The production
cultures are grown in a chemically defined protein-free medium consisting of
a mixture of amino acids, vitamins, inorganic salts and sugars. The final product,
prepared from the sterile filtrate culture fluid contains proteins, including
the 83kDa protective antigen protein, released during the growth period and
contains no dead or live bacteria. The final product is formulated to contain
1.2 mg/mL aluminum, added as aluminum hydroxide in 0.85% sodium chloride. The
final product is formulated to contain 25 µg/mL benzethonium chloride and
100 µg/mL formaldehyde, added as preservatives.

What are the possible side effects of anthrax vaccine (Biothrax)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with anthrax is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely...

Read All Potential Side Effects and See Pictures of BioThrax »

What are the precautions when taking anthrax vaccine adsorbed emergent biosolutions (BioThrax)?

Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), bleeding disorders (such as hemophilia, thrombocytopenia).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

It is unknown if this medication passes into breast milk. Consult your doctor before...

Read All Potential Precautions of BioThrax »

BioThrax Consumer (continued)

SIDE EFFECTS: Pain/redness/swelling at the injection site, limited arm movement, muscle ache, headache, or tiredness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US, you may report side effects to the Vaccine Adverse Event Reporting System (VAERS) at 1-800-822-7967. In Canada, you may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before receiving this vaccine, tell your doctor or pharmacist if you are allergic to it; or to latex; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before receiving this vaccination, tell your doctor or pharmacist your medical history, especially of: current fever/illness, immune system problems (such as HIV infection), bleeding disorders (such as hemophilia, thrombocytopenia).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

BioThrax Patient Information Including Side Effects

Brand Names: Biothrax

Generic Name: anthrax vaccine (Pronunciation: ANTH rax vax EEN)

• What is anthrax vaccine (BioThrax)?


• What are the possible side effects of anthrax vaccine (BioThrax)?


• What is the most important information I should know about anthrax vaccine (BioThrax)?


• What should I discuss with my health care provider before receiving anthrax vaccine (BioThrax)?


• How is anthrax vaccine given (BioThrax)?


• What happens if I miss a dose (BioThrax)?


• What happens if I overdose (BioThrax)?


• What should I avoid before or after receiving anthrax vaccine (BioThrax)?


• What other drugs will affect anthrax vaccine (BioThrax)?


• Where can I get more information?

What is anthrax vaccine (BioThrax)?

Anthrax is a disease caused by infection with a spore-forming bacteria. It usually occurs in animals such as sheep, goats, cattle, deer, antelope, and other herbivores. Anthrax can also occur in people who are exposed to an infected animal or other source of the anthrax bacteria.

Anthrax is spread to a human through the skin, the stomach, or the lungs. The bacteria can enter the skin through a cut or wound that comes into contact with products from an infected animal (such as meat, wool, hide, or hair). Infection can also occur through the lungs when a person inhales the bacterial spore, or through the stomach when a person eats undercooked meat from an infected animal.

Anthrax is most common in agricultural regions lacking in good veterinary prevention programs, especially in Africa, Asia, Central and South America, the Carribean, the Middle East and Southeastern Europe. Although less common, anthrax does occur in the United States each year among both wild game animals and domestic livestock.

Anthrax is a serious disease that can spread quickly throughout the body and it is fatal in a high number of cases, especially when acquired through the lungs.

The anthrax vaccine is used to help prevent this disease in people exposed to the bacteria through the skin or lungs. This vaccine works by exposing you to an antigen protein that causes your body to develop immunity to the disease. Anthrax vaccine does not contain live or killed forms of the bacteria that causes anthrax.

Anthrax vaccine will not treat an active infection that has already developed in the body.

Like any vaccine, the anthrax vaccine may not provide protection from disease in every person.

What are the possible side effects of anthrax vaccine (BioThrax)?

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with anthrax is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect (some are rare but serious) such as:

• severe swelling or a hard lump where the shot was given;


• severe swelling spreading to other parts of your arm;


• fever, chills, body aches, nausea, flu symptoms;


• pale skin, easy bruising or bleeding;


• confusion, changes in mood or behavior;


• seizure (convulsions);


• blistering, redness, and swelling or warmth of the skin;


• weakness, numbness or tingly feeling in your feet spreading upward;


• problems with vision, hearing, speech, swallowing, or bladder and bowel functions;


• severe lower back pain; or


• slow heart rate, trouble breathing, weak pulse, or feeling like you might pass out.

Less serious side effects include:

• mild redness, warmth, itching, or tenderness where the shot was given;


• low fever;


• feeling tired or weak;


• headache, dizziness;


• mild pain or stiffness in the injected arm;


• joint or muscle pain;


• swelling in your hands or feet; or


• mild skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about anthrax vaccine (BioThrax)?

You should not receive this vaccine if you have ever had a life-threatening allergic reaction to an anthrax vaccine, or if you have ever had anthrax disease acquired through the skin.

Before receiving this vaccine, tell the doctor if you have ever had an allergic reaction to a vaccine, or if you have a weak immune system, if you are pregnant or breast-feeding, if you are allergic to latex rubber, if you are receiving chemotherapy or radiation, or if you have a history of Guillain-Barré syndrome.

You can still receive a vaccine if you have a cold or mild fever. In the case of a more severe illness with a high fever or any type of infection, wait until you get better before receiving this vaccine.

Before receiving anthrax vaccine, tell the doctor about all other vaccines you have recently received. Also tell the doctor if you have recently received drugs or treatments that can weaken the immune system, such as steroids, psoriasis or arthritis medications, medicines to treat or prevent organ transplant rejection, or chemotherapy or radiation treatments. You may not be able to receive the anthrax vaccine, or may need to wait until the other treatments are finished.

Becoming infected with anthrax is much more dangerous to your health than receiving the vaccine to protect against it. Like any medicine, this vaccine can cause side effects, but the risk of serious side effects is extremely low.

Anthrax vaccine will not treat an active infection that has already developed in the body.

Related Drug Centers

• BioThrax

PrismaSol Solution

DRUG DESCRIPTION

PrismaSol solution (sterile hemofiltration hemodiafiltration solution) is a clear, sterile solution free of bacterial endotoxins.
This solution is used in Continuous Renal Replacement Therapies (CRRT) as a
replacement solution in hemofiltration and hemodiafiltration.

It contains no bacteriostatic or antimicrobial agents.

PrismaSol solution (sterile hemofiltration hemodiafiltration solution) is packaged in a two-compartment bag. The small compartment
A contains electrolytes and the large compartment B contains buffer. The final
reconstituted solution (5000 mL) is obtained after breaking the red frangible
pin between compartments A and B and mixing both solutions. The compositions
of the solution before and after reconstitution are described in the following
tables.

BEFORE RECONSTITUTION

1000 mL of electrolyte solution (small compartment A) contains
(g)

	PrismaSol BGK 4/2.5	PrismaSol BGK 2/3.5	PrismaSol BGK 0/2.5	PrismaSol B22GK 4/2.5
Calcium chloride•2H2O	3.68	5.15	3.68	3.68
Magnesium chloride•6H2O	3.05	2.03	3.05	3.05
Dextrose anhydrous	20.0	20.0	20.0	20.0
(as dextrose monohydrate)	22.0	22.0	22.0	22.0
Lactic acid	5.40	5.40	5.40	5.40

1000mL of buffer solution (large compartment B) contains
(g)

	PrismaSol BGK 4/2.5	PrismaSol BGK 2/3.5	PrismaSol BGK 0/2.5	PrismaSol B22GK 4/2.5
Sodium chloride	6.46	6.46	6.46	7 .07
Sodium bicarbonate	3.09	3.09	3.09	2.21
Potassium chloride	0.314	0.157	0	0.314

1000 mL of electrolyte solution (small compartment A) contains
(g)

	PrismaSol BGK4/0/1.2	PrismaSol BGK 2/0	PrismaSol B22GK4/0	PrismaSol B22GK 2/0	PrismaSol BK 0/0/1.2	PrismaSol BK 0/3.5
Calcium chloride•2H2O	0	0	0	0	0	5.15
Magnesium chloride•6H2O	2.44	2.03	3.05	3.05	2.44	2.03
Dextrose anhydrous	20.0	20.0	20.0	20.0	0	0
(as dextrose monohydrate)	22.0	22.0	22.0	22.0	0	0
Lactic acid	5.40	5.40	5.40	5.40	5.40	5.40

1000 mL of buffer solution (large compartment B) contains
(g)

	PrismaSol BGK4/0/1.2	PrismaSol BGK 2/0	PrismaSol B22GK 4/0	PrismaSol B22GK 2/0	PrismaSol BK 0/0/1.2	PrismaSol BK 0/3.5
Sodium chloride	6.46	6.46	7.07	7.07	6.46	6.46
Sodium bicarbonate	3.09	3.09	2.21	2.21	3.09	3.09
Potassium chloride	0.314	0.157	0.314	0.157	0	0

AFTER RECONSTITUTION of compartments A and B

1000 mL of the reconstituted solution contains

in mEq/L except where noted	PrismaSol BGK 4/2.5	PrismaSol BGK 2/3.5	PrismaSol BGK 0/2.5	PrismaSol B22GK 4/2.5
CalciumCa2+	2.5	3.5	2.5	2.5
Bicarbonate HCO3	32	32	32	22
Potassium K+	4.0	2.0	0	4.0
Magnesium Mg2+	1.5	1.0	1.5	1.5
Sodium Na+	140	140	140	1140
Chloride Cl	113	111.5	109	123
Lactate	3.0	3.0	3.0	3.0
Dextrose	100 mg/dL	100 mg/dL	100 mg/dL	100 mg/dL
Theoretical	300 mOsm/L	296 mOsm/L	292 mOsm/L	300 mOsm/L

in mEq/L except where noted	PrismaSol BGK 4/0/1.2	PrismaSol BGK 2/0	PrismaSol B22GK 4/0	PrismaSol B22GK 2/0
Calcium Ca2+	0	0	0	0
Bicarbonate HCO3	32	32	22	22
Potassium K+	4.0	2.0	4.0	2.0
Magnesium Mg2+	1.2	1.0	1.5	1.5
Sodium Na+	140	140	140	140
Chloride Cl	110.2	108	120.5	118.5
Lactate	3.0	3.0	3.0	3.0
Dextrose	100 mg/dL	100 mg/dL	100 mg/dL	100 mg/dL
Theoretical Osmolarity	295 mOsm/L	295 mOsm/L	295 mOsm/L	295 mOsm/L

In mEq/L except where noted	PrismaSol BK 0/0/1.2	PrismaSol BK 0/3.5
Calcium Ca2+	0	3.5
Bicarbonate HCO3	32	32
Potassium K+	0	0
Magnesium Mg2+	1.2	1.0
Sodium Na+	140	140
Chloride Cl	,106.2	109.5
Lactate	3.0	3.0
Dextrose	0	0
Theoretical Osmolarity	282 mOsm/L	287 mOsm/L

Calcium chloride, USP, is chemically designated calcium chloride dihydrate
(CaCl₂•2 H₂O).

Magnesium chloride, USP, is chemically designated magnesium chloride hexahydrate
(MgCl₂•6H₂O).

Dextrose, USP, is chemically designated D-Glucose anhydrous (C₆H₁₂O₆)
or D-Glucose monohydrate (C₆H₁₂O₆•H₂O).

Lactic acid, USP, is chemically designated CH₃CH(OH)COOH.

Sodium chloride, USP, is chemically designated NaCl.

Potassium chloride, USP, is chemically designated KCl.

Sodium bicarbonate, USP, is chemically designated NaHCO₃.

The pH of the final solution is in the range of 7.0 to 8.5.

Solutions in contact with the plastic container can leach out certain of its
chemical components in very small amounts within the expiration period, e.g.
di 2-ethylhexyl phthalate (DEHP), up to 3 parts per milion; however, the safety
of the plastic has been confirmed in tests in animals according to USP biological
tests for plastic containers as well as by in-vitro toxicity studies.

Chloroptic

(Generic versions may still be available.)

DRUG DESCRIPTION

Chloroptic® (chloramphenicol ophthalmic solution, USP) is a topical anti-infective product for ophthalmic use.

Structural Formula

C₁₁H₁₂Cl₁₂N₂0₅

Mol Wt 323.13

Chemical Name:

D-threo-(-)-2,2-Dichloro-N-143-hydroxy-a-(hydroxymethyl)..

p-nitrophenethyl] acetamide

Contains:

Active: chloramphenicol	0.5% (5mg/ml)
Preservative: chlorobutanol (chloral deny.)	0.5%;

Inactives: polyethylene glycol 300; polyoxyl 40 stearate; sodium hydroxide or hydrochloric acid to adjust PH; and purified water.

What are the possible side effects of chloramphenicol ophthalmic (Chloroptic, Chloroptic S.O.P.)?

Serious side effects are not expected with this medication. Rarely, prolonged use of this medication has damaged bone marrow. Call your doctor if you experience extreme fatigue or unusual bleeding or bruising.

More commonly, some burning, stinging, irritation, itching, redness, blurred vision, or sensitivity to light may occur. Continue to use chloramphenicol ophthalmic and talk to your doctor about any side effects that you...

Read All Potential Side Effects and See Pictures of Chloroptic »

What are the precautions when taking chloramphenicol (Chloroptic)?

Before using chloramphenicol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an eye infection due to a virus (e.g., herpes, varicella), another type of eye infection (e.g., tuberculosis, fungus), history of a bad reaction to chloramphenicol.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, anemia (low red blood cells), radiation therapy.

After you apply...

Read All Potential Precautions of Chloroptic »

Chloroptic Consumer (continued)

SIDE EFFECTS: See also Warning section.

Temporary blurred vision, burning, stinging, or redness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: vision changes/problems.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using chloramphenicol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: an eye infection due to a virus (e.g., herpes, varicella), another type of eye infection (e.g., tuberculosis, fungus), history of a bad reaction to chloramphenicol.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, anemia (low red blood cells), radiation therapy.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly needed. This medication should not be used near or at the time of delivery due to possible harm to the newborn (gray baby syndrome). Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Chloroptic Patient Information Including Side Effects

Brand Names: Chloroptic, Chloroptic S.O.P.

Generic Name: chloramphenicol ophthalmic (Pronunciation: klor am FEN i kole)

• What is chloramphenicol ophthalmic (Chloroptic)?


• What are the possible side effects of chloramphenicol ophthalmic (Chloroptic)?


• What is the most important information I should know about chloramphenicol ophthalmic (Chloroptic)?


• What should I discuss with my healthcare provider before using chloramphenicol ophthalmic (Chloroptic)?


• How should I use chloramphenicol ophthalmic (Chloroptic)?


• What happens if I miss a dose (Chloroptic)?


• What happens if I overdose (Chloroptic)?


• What should I avoid while using chloramphenicol ophthalmic (Chloroptic)?


• What other drugs will affect chloramphenicol ophthalmic (Chloroptic)?


• Where can I get more information?

What is chloramphenicol ophthalmic (Chloroptic)?

Chloramphenicol is an antibiotic.

The ophthalmic form of chloramphenicol is used to treat bacterial infections of the eyes.

Chloramphenicol ophthalmic may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of chloramphenicol ophthalmic (Chloroptic)?

Serious side effects are not expected with this medication. Rarely, prolonged use of this medication has damaged bone marrow. Call your doctor if you experience extreme fatigue or unusual bleeding or bruising.

More commonly, some burning, stinging, irritation, itching, redness, blurred vision, or sensitivity to light may occur. Continue to use chloramphenicol ophthalmic and talk to your doctor about any side effects that you experience.

What is the most important information I should know about chloramphenicol ophthalmic (Chloroptic)?

Contact your doctor if your symptoms begin to get worse or if you do not see any improvement in your condition after a few days.

Do not touch the dropper or tube opening to any surface, including your eyes or hands. The dropper or tube opening is sterile. If it becomes contaminated, it could cause an infection in your eye.

Apply light pressure to the inside corner of your eye (near your nose) after each drop to prevent the fluid from draining down your tear ducts.

Related Drug Centers

• Chloroptic

Caffeine and Sodium Benzoate Injection

DRUG DESCRIPTION

Caffeine and Sodium Benzoate Injection, USP (caffeine alkaloid) is a clear, sterile, nonpyrogenic,
solution of Caffeine Alkaloid.

Each mL contains: Caffeine (anhydrous) 125 mg; Sodium Benzoate (added to increase
the solubility of Caffeine) 125 mg; Water for Injection, USP q.s. pH (range
6.5 to 8.5) adjusted with Hydrochloric Acid and/or Sodium Hydroxide. For intramuscular
or slow intravenous administration only.